Breast cancer resistance protein 意味
WebJun 1, 2024 · Breast cancer resistance protein (BCRP) is expressed on the apical membrane of small intestinal epithelial cells and functions as an efflux pump with broad substrate recognition. Therefore, quantitative evaluation of the contribution of BCRP to the intestinal permeability of new chemical entities is very important in drug research and … This protein is a member of the White subfamily. Alternatively referred to as the breast cancer resistance protein (BCRP), this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues. See more ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation … See more It is inhibited by some calcium channel blockers such as amlodipine, felodipine and nifedipine. The fungal toxin fumitremorgin C (FTC) inhibits the protein but has neurotoxic side … See more • ABCG2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Human ABCG2 genome location and ABCG2 gene details page in the See more The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The active transport of chemicals … See more • ATP-binding cassette transporter See more • Hazai E, Bikádi Z (April 2008). "Homology modeling of breast cancer resistance protein (ABCG2)". Journal of Structural Biology. 162 (1): 63–74. doi: • Abbott BL (January 2006). … See more
Breast cancer resistance protein 意味
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WebApr 1, 2002 · Abstract. Purpose: The breast cancer resistance protein (BCRP) is involved in in vitro multidrug resistance and was first identified in the breast cancer cell line MCF7/AdrVp. The aim of this study was to investigate the role of BCRP in resistance of breast cancer to anthracycline treatment.Experimental Design:BCRP mRNA was … WebJun 12, 2024 · Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have been developed, but most of them fail in clinical trials due to severely adverse effects. Recently, certain natural products have been reported to overcome …
WebBCRP was originally identified as a multidrug resistance protein in cancer cells. It is expressed in mammary tissue, testis, placenta, and the gastrointestinal tract, kidney, … WebSep 1, 2004 · Gefitinib inhibits the transporter function of BCRP and reverses B CRP-mediated drug resistance both in vitro and in vivo, and suggests that gefit inib may overcome BCRp- mediated drug resistance by inhibiting the pump function ofBCRP. Breast cancer resistance protein (BCRP) is an ATP binding cassette transporter that confers …
WebNov 8, 2011 · In dozens of experiments in mice and in human cancer cells, a team of Johns Hopkins scientists has closely tied production of a cancer-causing protein called TWIST … WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.
WebFeb 9, 2010 · Breast cancer anti-estrogen resistance protein 1. Gene. BCAR1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 870. …
Web2.2 Breast cancer resistance protein (BCRP) BCRP is encoded by ABCG2, and received its name based on its ability to confer drug resistance in breast cancer cell lines (Jani … rudolph hennig junior highWebMar 3, 2024 · 因此，对多药耐药（multidrug resistance，MDR）机制的研究仍是当今肿瘤研究领域的一个热点。 ... glycoprotein，P-gp）、MDR 相关蛋白（multidrugresistanceassociated protein，MRP）、乳腺癌耐药蛋白（breast cancer resistance protein，BCRP）等。 ... 的敏感性下降，从而产生耐药；二是 ... scape and run parasites reekerWebNov 16, 2024 · P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response against medications, including … rudolph hennig fort saskatchewanWebATP binding cassette (ABC)-containing drug efflux transporters play important roles in regulating intracellular drug concentrations that determine cell sensitivity to chemotherapeutic agents. Of particular relevance to … rudolph hennig junior high fort saskatchewanWebMar 5, 2024 · The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in cancer like other … scape and run parasite wikiWebAug 24, 2024 · BCRP: breast cancer resistance protein; MATE: multidrug and toxin extrusion protein; MRP2: multidrug resistance-associated protein 2; OAT: organic anion transporter; OATP: organic anion ... scape and run: parasites wikiWebWikipedia rudolph hennig school fort saskatchewan